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doi: 10.3389/fimmu.2017.01198

For controlled skin studies, topical application removes the confounders introduced by injection no injection site reactions, no systemic distribution diluting local concentration, no injection technique variability across research subjects

In addition to Nrf2, activation of PPAR- and the AMPK pathway can also facilitate the GSH system

They recruit and activate innate immune cells (such as macrophages) and promote local inflammation and tissue damage