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However, in chronic critical illness, glutathione synthesis may be impaired by cysteine depletion, protein-energy malnutrition, hyperglycemia, pharmacological doses of glucocorticoids, and decreased anterior pituitary hormone secretion

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Garnham al,mcdonald JA,Weeden CE,Anderson D,Pirman D,Roddy TP,Creek DJ,Kallies A,Kingsbury G,Sutherland KD

Mitochondrial modulation by Epigallocatechin 3-Gallate ameliorates cisplatin induced renal injury through decreasing oxidative/nitrative stress, inflammation and NF-kB in mice

The missing pieces are big: no human dosing, no human pharmacokinetics, no controlled human safety data, and no long-term outcome data in any species