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Delivery of therapeutics Viral delivery of CRISPR-Cas9 gene constructs and ASOs have been a commonly used method that utilizes vectors such as lentiviruses, adenoviruses, and adeno-associated viruses (AAV) [141] (Table 1)

Studies are planned to further evaluate NPI-001 and NPI-002 as potential treatments for AMD and Stargardt disease

Doubling up to 'catch up' creates unnecessary gastrointestinal stress without proportional therapeutic benefit, as glutathione absorption is dose-limited by intestinal transport capacity (approximately 200300mg per administration for oral forms)

In summary, immune dysfunction in UC comprises exaggerated effector responses coupled with defective regulatory control