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The results of comparing healthy controls and patients with A pathology alone with A together with tau pathology indicate that A is associated with disturbances in iron balance, as evidenced by lower NCOA4 expression, and a decrease in GPX4 antioxidant enzyme expression in the grey matter

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Importantly, homocysteine levels, which should be around 7.0, can be increased due to folic acid deficiency independent of B12 deficiency

J Nutr 142:14101416 Lobb RJ, Jacobson GM, Cursons RT, Jameson MB (2018) The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells

Because H 2 S and Fe 2+ are abundant in hydrothermal environments, primitive organisms likely extracted two electrons of reducing power from oxidation of H 2 S, which then coupled with Fe 2+ , yielding pyrite (FeS 2 )[20]