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Further research will have to be carried out to explain this dilemma

Evaluation on liver enzymes revealed constitutive induction of CYP2E1 and ALDH1A1 in untreated GCLM KO mice

The US Public Health Service recommends that women of reproductive age take a daily dosage of folate (0.4 mg) before getting pregnant to reduce the risk of non-transformed disorders

However, data obtained from most experiments dealing with in vitro cell exposure to homocysteine are disappointing because the concentrations required are generally high and the effects generally have not been specific to homocysteine (Jacobsen, 1993)

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