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A 2014 publication (McCoy et al., Journal of Pharmacology and Experimental Therapeutics) was retracted due to concerns about data fabrication

Disclaimer: Comprehensive human safety data for these peptides are limited

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MOTS-c: the mitochondrial peptide for disc cell survival MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial genome that has recently emerged as a promising candidate for intervertebral disc degeneration