In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]
carcinogenicity, mutagenicity, reproductive toxicity, respiratory sensitization, target organ toxicity from repeated exposure, or aspiration hazard
doi: 10.1172/JCI11916 111 McGeerP
[DOI] [PubMed] [Google Scholar] 74.Singletary K.W
These micronutrients coexist in a state of dynamic equilibrium, wherein their interactions are crucial