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Abudawood M, Tabassum H, Alanazi AH, et al

However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

Due to its instability, the cystine/glutamate antiporter (xCT) plays a pivotal role in cystine uptake [91,92,93]

Analysis suggested an early stress induced changes in the expression of genes with functional redundancy and precise involvement of GSTs in the oxidative stress protection (Sappl et al., 2009)

Oxidatively modified proteins in aging and disease