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14 This reverses previous perceptions and establishes that lactate is a proximate fuel for the TCA cycle

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

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However, the underlying mechanism by which MTX provokes tissue injury is not yet well known, and direct toxic effects of MTX are thought to be caused by excessive generation of free radicals, causing an imbalance between free radical production and antioxidant defense, which finally results in the development of oxidative stress (Drishya et al

Building and Engineering Complex Biological Systems Cell-free systems derive benefits from the lack of viability constraints, but defining features of cells, such as compartmentalization and self-replication, can also be valuable in nonliving contexts