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Retrieved 21 April 2020

The relationship between tirzepatide and menstrual irregularities is primarily indirect, mediated through significant weight loss and metabolic improvements

Gastrointestinal effects usually settle across the first month, then return temporarily after each increase

[ref] Related article: NOS3 gene and nitric oxide Gut-brain axis: Nerves running from the brain to the intestines can move neurotransmitters and send signals in both directions