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Antiepileptic drugs like topiramate and zonisamide, which have sedative properties, were associated with cognitive impairments

Abnormal accumulation of fluidedema, ascites, pleural effusioncan markedly increase the volume of distribution of drugs such as gentamicin that are hydrophilic and have small volumes of distribution

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Stimulation of collagen, elastin, and glycosaminoglycan synthesis in fibroblasts

To decrease your risk of leaky gut syndrome, focus on improving your gut health by eating a healthy diet and limiting your use of NSAIDs.