Abbreviations ATP: Adenosine triphosphate c-Met (HGFR): Hepatocyte growth factor receptor EGFR: Epidermal growth factor receptor EMT: Epithelial mesenchymal transition HGF: Hepatocyte growth factor MAPK: Mitogen-activated protein kinase MET: Mesenchymal-to-epithelial transition MM: Malignant melanoma NF-B: Nuclear factor-B NK cells: Natural killer cells PDGFR: Platelet-derived growth factor receptor PI3K: Phosphatidylinositol-3 kinase PTKs: Protein tyrosine kinases Rel3 (EGFP-A375/Rel3): Hypermetastatic human malignant melanoma cell line derived from EGFP-A375 RTKs: Receptor tyrosine kinases TGF-: Transforming growth factor-Beta References Lambert AW, Pattabiraman DR, Weinberg RA
CBD has no mucolytic mechanism NMDA modulation for mental health: NAC's glutamate-reducing NMDA mechanism has documented clinical efficacy for OCD (Lafleur et al., 2006), addiction craving (Mardikian et al., 2007), and bipolar depression a different mental health mechanism from CBD's serotonergic approach, relevant to conditions where glutamate excitotoxicity rather than serotonin dysregulation is the primary driver Antioxidant Mechanisms: Direct vs Indirect The antioxidant comparison between CBD and NAC is the most mechanistically important distinction in this comparison and the result is clear:NAC is a more direct and more potent antioxidant than CBD for most applications
The goal is to choose the form that fits your body and your treatment plan
Currently, the concentration of intracellular GSH is derived from either cell lysates or GSH- S -transferase (GST) dependent probes 7,8
Health insurance generally doesnt cover wellness IV therapy in the US, because it isnt classified as medically necessary care for a diagnosed condition
