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In 2 retrospective studies of ketamine for the treatment of refractory headache, which included individuals with chronic migraine, continuous subanesthetic doses of intravenous ketamine reduced headache severity acutely when dosed from 0.1 mg/kg/h to a maximum of 1 mg/kg/h titration based on drug tolerability

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NT5C2 is the enzyme responsible for catalyzing the hydrolysis of inosine monophosphate (IMP) and guanosine monophosphate (GMP)

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