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The extended half-life of tirzepatideapproximately 120 hoursmeans that therapeutic drug concentrations remain relatively stable throughout the dosing interval

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In some embodiments, the otoprotectant is a compound comprising a urea-thiophene-carboxamide moiety of Formula (IV): wherein X is a heteroatom that includes N, 0, or S

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Sci Rep 7 , 2604 (2017)