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For example, 72 weeks of treatment with tirzepatide in people with obesity (without diabetes, SURMOUNT-1 trial), resulted in an overall improvement of the total fat mass: total lean mass ratio, but there was a 10.9% reduction of total lean mass at the end of the study [22]

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The peptide successfully heals internal fistulas (gastrocutaneous, duodenocutaneous, and colocutaneous) in experimental models, achieving fistula closure even when treatment is delayed for one month after fistula formation