First, it disrupts the process of melanin synthesis by inducing the release of high mobility group box 1 (HMGB1) protein, thus downregulating the melanin biosynthesis-related proteins: melanocyte-inducing transcription factor, tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, RAB27A and fascin actin-bundling protein 1 [17, 18]
Thyroid hormone imbalances can also affect skin quality, with hypothyroidism sometimes causing dry, loose-appearing skin
Injecting each dose into a different area of skin allows time for each site to recover
Injection to a nerve may cause some amount of pain initially but at tolerable levels
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