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Treatment Treatment usually involves vocal training, speech therapy, and, occasionally, vocal rest

mechanism remains an active area of study

While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)

J Biol Chem 229:189197 Rotruck JT, Pope AL, Ganther HE et al (1973) Selenium: biochemical role as a component of glutathione peroxidase

Vitamin K Both -tocopherol and phylloquinone (vitamin K 1 ) are fat-soluble vitamins and share similar side chains