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Collectively, microglia promote inflammatory cycles via the NLRP3 pathway, while astrocyte dysfunction exacerbates glutamate toxicity and BBB dysregulation

Concentrations of pyruvate which maintain PDH in the active form are sufficiently high so that, in energy-rich cells, the allosterically down-regulated, high K m form of PDH is nonetheless capable of converting pyruvate to acetyl-CoA

Arterial blood pressure variability and other vascular factors contribution to the cognitive decline in parkinsons disease

Safety posture: No serious adverse events have been reported in published studies

doi: 10.1016/j.ejphar.2018.03.002 100 ChenFZhengS-LHuJ-NSunYHeY-MPengHet al