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Consequently both them and us are being done a disservice

Long-term side effects of NAD treatment have not been described

A healthier gut is a more efficient gut

Elevated NNMT is linked to: Reduced NAD+ availability Slower mitochondrial function Increased fat storage efficiency Higher risk for insulin resistance By reducing NNMT activity, 5-Amino-1MQ allows the body to maintain higher NAD+ levels, which can support better mitochondrial performance, improved fat oxidation, and more balanced energy metabolism

This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%