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the BMDL value of E Cd /C cr leading to a 5% reduction in eGFR was 0.0215 g/L of filtrate for both men and women [47]

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By extrapolating complex scenarios observed in vitro while having in mind that intrinsic and extrinsic factors can alter the kinetic values, one can identify optimal dosing regimens for individual patients (Rostami-Hodjegan 2012

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