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GLP-1 receptors exist in the dorsal vagal complex of the brainstem

In certain embodiments, any otic formulation or composition described herein has an endotoxin level of less than 0.5 EU/kg, less than 0.4 EU/kg or less than 0.3 EU/kg

PMID 33617860 Elamipretide (SS-31): +3 charge, mitochondrial cardiolipin accumulation, and injection-site-reaction profile (review)

Both peptides also show overlapping anti-inflammatory signals in separate studies, with each associated with reduced pro-inflammatory cytokines such as IL-6 and TNF-alpha in animal models