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Activation of IGF-1R results in the recruitment and phosphorylation of multiple adaptor proteins including insulin receptor substrates (IRSs) and Shc, leading to activation of two pro-survival signaling pathways

PGC-1 activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer

Reactive oxygen species (ROS) such as hydrogen peroxide and alkylperoxides produced by various metabolic processes can cause irreversible oxidative damage to the cell if they are not rapidly detoxified by antioxidant defenses

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