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In rats, both acute (4-h) and subchronic (7-day) cagrilintide treatment increased predicted Fos regulon activity in Glu4.2 Calcr/Ramp3 cells (adjusted P value ( P adj ) = 0.037 and P adj = 0.026, respectively

doi: 10.1074/jbc.M010123200 25 BirdKARamosAAKliebensteinDJ

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For SARS-CoV-2, divalent IgG binding has been shown to lead to more potent neutralization and more effective shedding of the S1 subunit, which will render Env spikes non-infectious, than does monovalent Fab binding 21

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