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These approaches are mechanistically complementary one adds substrate, the other prevents its degradation

consequently creating a cellular oxidative environment which triggers the oxidation of essential biomolecules like DNA, protein and lipids, leading to multiple disease conditions

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Microglia, neurons, astrocytes, and endothelial cells can release proinflammatory cytokines and chemokines, modulating adhesion molecules and transmigration of activated immune cells into the brain parenchyma (Jickling et al., In addition, the increase in cellular levels of TNF- and IL-1 has been related to the decrease in occludin expression and ZO-1 and 2 in the hypoxic brain (Rochfort and Cummins, 2015