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Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression

Disruption of the M6P pathway results in the mistargeting of most lysosomal enzymes and a severe lysosome storage disease, Mucolipidosis type II (MLII) 3

Additionally, the time frames of patient involvement are different and there may have been advances in supportive care or other therapies since the timeframe for historical controls (2010-2013)