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Zinc predominantly functions as a cofactor in enzymes, stabilizing protein structures through its interaction with specific amino acid residues, such as cysteine and histidine, thereby contributing to the secondary and tertiary of target proteins [49, 50]
Sulfur-containing amino acids (SAAs) like cysteine and methionine form disulfide bonds and undergo reversible S-glutathionylation, S-nitrosylation, and S-persulfidation that contribute to peroxidase, dehydroascorbate reductase, and transcription factor activity, thereby stabilizing the glutathione-to-glutathione disulfide (GSSG) redox couple
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SPRAVATO (esketamine) nasal spray is indicated for the treatment of: Treatment-resistant depression (TRD) in adults as monotherapy or in conjunction with an oral antidepressant
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