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96 Safety B12 is considered safe even at high doses, and no adverse effects have been associated with excess B12 in healthy individuals

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Application of flow karyotyping and fluorescence in situ hybridization to detection of chromosome aberrations

This result is not consistent with previous studies that have investigated the link between low Se levels and thyroid cancer

Animal models frequently employ single high doses or repeated supraphysiological doses (e.g., 100200 mg/kg, i.p.) to induce rapid ovarian failure, while human chemotherapy protocols typically involve lower fractionated doses administered over longer periods