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Regulation of IGF-1R is mainly achieved at the transcriptional level through transcription factors interfering with the GC-rich initiator motif (lacking TATA and CCAAT boxes) of the IGF-1R promoter in either a stimulatory or inhibitory fashion

Cyanocobalamin is hygroscopic in the anhydrous form, and sparingly soluble in water (1:80)

These proteins not only act as receptors, they also modulate signaling pathways

The limma R software package (adjusted p 1) was used to screen differentially expressed genes (DEGs)

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