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Description

A win at all costs approach is dangerous

JCI Insight (2021) 6(24)

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Dihexas trajectoryfrom claims of being seven orders of magnitude more potent than BDNF in rodents to a failed Phase 2/3 trial and retracted foundational researchexemplifies this valley of death. This pattern demands particular caution when extrapolating from compelling animal data to expectations for human cognitive benefit