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That introduces the exact error the calculator exists to prevent

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Pharmacotherapy While data on analgesic safety and efficacy in patients with cirrhosis remain limited, a general principle of cautious initiation at low doses with slow titration applies across drug classes (Table 1)

Although we were not able to find any studies concerning the effects of VIP on muc5B regulation and/or expression in asthma, since muc5B might be decreased in asthma [119], and VIP might also be decreased, then one speculation is that VIP directly stimulates production of muc5B