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Contagious Susceptibility: Vulnerable senescent cells pass their ferroptosis susceptibility to neighboring healthy cells, explaining how a small population of senescent cells can spread tissue dysfunction during aging

Millea PJ

It can range from simple steatosis to inflammation and fibrosis, and eventually lead to irreversible liver cirrhosis (Tanaka et al., 2020)

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Disruption of the BBB including compromised BBB integrity and subsequent leakage of plasma constituents into the brain parenchyma, and impaired BBB dysfunction consisting of compromised transport system, reduced CBF, and heightened vascular inflammatory response at the BBB level, which are closely interlinked with the accumulation of A and the presence of neurofibrillary tangles [137]