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When mitochondrial function is impaired, enzyme complex IV in the inner mitochondrial membrane fails to produce water as it should, resulting in the production of O 2 -, which subsequently convert into OH and H 2 O 2

Lyubartseva, G., Smith, J

J Neurochem 120:147156 Tinggi U (2008) Selenium: Its role as antioxidant in human health

302 Transmission of Wnt3a--catenin signal exhausted tumour infiltrating T cells, thus weakening their anti-tumour effects, and inhibiting the production of effector memory T cells