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Interestingly, zinc imbalance has been linked to the hypermethylation and silencing of zinc transporters such as ZIP8 and ZIP13, suggesting a feedback loop between zinc status, transporter expression and nuclear epigenetic regulation 116,117

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1995 Oct 26;333(17):110610

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For treatment of confirmed deficiency , NHS protocols typically involve hydroxocobalamin injections: initially 1mg three times a week for two weeks for those without neurological involvement, followed by maintenance injections every 2-3 months