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Acetyl-carnitine synthetized in mitochondria by CrAT is transported out mitochondria by CACT and transformed back to acetyl-CoA by CrAT present in the nucleus

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Given that supplementing diets with pro- or pre-biotics typically increases gut microbial fatty acid production, and that fats are fatty-acid compounds, it is interesting to note that an unsupplemented diet poor in carbohydrates, no more than adequate in protein, but high in fats, has repeatedly been found to produce similar benefits

doi: 10.1177/0300985809353313