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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

Anxiety / stress response Investigated as an anxiolytic in Russian clinical research on generalized anxiety

Energy may improve briefly, and that can lead to behavior changes that sometimes subtly change weight, but the vitamin itself is not a fat-burning drug

Importantly however, animal studies collectively emphasize two key principles: first, an adaptive T- and B-cell response can be elicited by myelin that degenerates in a specific way, without any deliberate upregulation of the systemic immune system

Blood Tests: Blood tests are more accurate and invasive but can detect substances circulating in the bloodstream, including peptides