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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

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Results LNP-mRNA system We optimized the LNP component to improve transfection efficiency by replacing cholesterol with an equal amount of -sitosterol (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Mouzakis FL, Khadka LB, Pereira da Silva M, Mottaghy K