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Second, the spatial and temporal resolution of human data is insufficient, and longitudinal multi-omics datasets across different ages and follicular stages are still lacking

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4-OH Metabolites CYP1b1 is the enzyme responsible for the metabolism of E1 to 4-OH-E1 and E2 to 4-OH-E2

Thus, the unique conditions within the endometriotic lesion, high iron, ROS, and persistent inflammation, likely converge to promote cellular senescence