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Bulletin of Experimental Biology and Medicine, 164 , 140-143

In conclusion, a therapeutic approach to IVD degeneration involving enhanced tissue repair by exogenous growth factors may be clinically important, but more research is needed to address the efficacy, duration of action, safety, and adverse effects of the growth factors administered in vivo

however, their effects on the reproductive system of patients are often overlooked, especially their impact on germ cell cytogenesis, embryonic development, and reproductive system maturation

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