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Moreover, potential bias and confounding factors were identified in the assumption that patients who develop irAEs remain on treatment longer and hence have a better outcome than their counterparts, and as such, could only be attributed to guarantee-time bias [74, 75]

Substrate scope assays of jr PPO1-wt and the five investigated mutants Substrate scope assays were performed using four monophenols (phenol, tyrosol, tyramine and L -tyrosine) and four diphenols (catechol, 4-tert-butylcatechol (4-TBC), dopamine and L -DOPA) (Figs

Blood samples were collected from the jugular vein of each horse

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IRE1 interacts with the adaptor protein TRAF2, leading to the activation of c-Jun N-terminal kinase (JNK) (Huang S