The gut microbiota-derived Pathogen-Associated Molecular Patterns, including LPS and peptidoglycan, are recognized by Pattern Recognition Receptors (PRRs), in particular Toll-like receptors and NOD-like receptors, which are expressed on osteoclasts and osteoblasts (236)
The oral-gut axis thus serves as a critical mediator in systemic inflammation and disease progression, with specific microbial taxa offering potential biomarkers for early detection, as seen in oral cancer where Haemophilus parainfluenzae and Rothia mucilaginosa are malignancy-associated (Nayyar et al., 2025)
From a Mercato Kid to a Next Big Food Entrepreneur 26:03|Some entrepreneurial journeys come full circle.When Simon Dayrit was growing up, he watched his parents build their business at Mercato Centrale
While preclinical evidence is robust, clinical translation remains hindered by challenges such as variable bioavailability, lack of standardized formulations, and insufficient large-scale human trials
Damaged mitochondria slow down and make less energy, reducing the efficacy and efficiency of bodily functions
