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In addition, transcriptomic analysis of brains of 2 independent SCA3 transgenic mouse models reported downregulation of genes involved in glutamatergic and alpha-adrenergic neurotransmission and alterations in CREB pathways, as well as in axon guidance molecules, some of these alterations being already present at presymptomatic ages [117, 122]

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Last year, FDA called on PCAC to evaluate whether a dozen peptide drugs should be eligible for compounding by licensed facilities

Corbin KD, Carnero EA, Allerton TD, Tillner J, Bock CP, Luyet PP, et al

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