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Recently, hypoxia-induced expression of the SLC1A5 variant was shown to be mediated by HIF-2 and to lead to metabolic reprogramming toward glutamine metabolism in pancreatic cancer cells 16

| Concentration | BAC Water | Doses at 1.0mg | Doses at 2.4mg | |---------------|-----------|----------------|----------------| | 5mg/mL | 4.0mL | 20 doses | ~8 doses | | 2.5mg/mL | 8.0mL | 20 doses | ~8 doses | **Note:** At 4mL+ of liquid, ensure you have a large enough syringe (5mL or two separate 3mL draws) to transfer all the BAC water accurately

A very important aspect of this compound is that it can cross BBB and it is able to protect cells from OS in many preclinical models of neurologic diseases, such as hypoxic-ischemic injury, AD, PD [292]

PT-141 showed dose-dependent increases in concentration and exposure, with statistically significant erectile responses at doses from 7mg, usually starting 30 minutes after administration [13]