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Insulin resistance present in approximately 6580% of cases, independent of body weight, and the primary driver of the androgenic environment in the ovary.[2] Androgen excess elevated testosterone, DHEA-S, or androstenedione, driving most of the visible symptoms: hirsutism, acne, scalp hair thinning, cycle disruption

1 The remarkably low incidence of hypoglycemia and significant weight loss associated with these agents have contributed to their increased use