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In addition, transcriptomic analysis of brains of 2 independent SCA3 transgenic mouse models reported downregulation of genes involved in glutamatergic and alpha-adrenergic neurotransmission and alterations in CREB pathways, as well as in axon guidance molecules, some of these alterations being already present at presymptomatic ages [117, 122]

Retinal functional assessment in Rho P23H/+ mice P23H/+ Electroretinograms for Rho P23H/+ mice were recorded in both eyes of each animal

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