Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction
Lee YJ, Han KD, Kim DH, Lee CH
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[5] Glutathione supplementation is generally considered safe with a low risk of adverse effects when used at typical supplementation doses
Conclusions This review of published studies indicates that evidence for the involvement of the -glutamyl cycle and trans-sulphuration pathway in autism spectrum disorders should be further explored with higher quality and lower risk bias studies to in order to ascertain the significance of these pathways with respect to clinical outcomes
