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PLoS ONE 5:e10074

Antioxidant properties UAE Clinical studies have found that Epithalon exhibits antioxidant properties by effectively neutralizing free radicals, which are unstable molecules that can cause cellular damage and accelerate aging

A dysbiotic microbiome can deconjugate estrogen in the gut and recirculate it

Also, optical/physical radiations (ultraviolet, visible light, infrared) as well as systemic drugs (chloroquine, fluphenazine, physostigmine, imatinib) and topical drugs (imiquimod, long-term use of topical steroid) have been reported as vitiligo promoters (Harris 2017

For example, if the hypothalamus fails to signal the pituitary gland to release ACTH, then the adrenal gland wont produce sufficient amounts of cortisol