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Much of that benefit is reported anecdotally and has not been confirmed in large, rigorous human trials

Likewise, SARS-Cov-2 infection and acute COVID-19 are accompanied by an inflammatory response [29], increased MPO activity [45], indicants of oxidative damage [46,47,48] and increased NO production including increased levels of nitrotyrosine [49], and lowered antioxidant defenses (ANTIOX) as indicated by reduced TAC levels [45, 49], Gpx [50], and zinc [51]

A clinical trial investigating the effects of curcumin on psychological status, inflammation, and oxidative damage markers in patients with type 2 diabetes and coronary heart disease (IRCT20170513033941N63) revealed reduced malondialdehyde (MDA) levels, increased total antioxidant capacity and glutathione (GSH) levels, and upregulated PPAR- gene expression in these patients (111)

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