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A visible sign of protein denaturation that reduces bioavailability by 1525% according to stability studies in Pharmaceutical Research

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Other possible causes of a vitamin B12 deficiency pernicious anemia prolonged use of certain medications, such as metformin following a strict vegan or vegetarian diet certain infections, such as with the tapeworm Diphyllobothrium latum celiac disease older age high intake of alcohol Other nutritional supplements may also benefit someone with Crohns disease