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However, the effectiveness of this treatment is still controversial

In mammals, PMEL fibrils have emerged as the first human functional amyloid described in the literature (Fowler et al., 2006)

It has even been found to act as an antioxidant to other antioxidants as it can maximize the activity of Vitamin C and Vitamin E

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Adaptive responses, such as endothelial cell proliferation, cytoskeletal reorientation, renin-angiotensin-aldosterone system (RAAS) activation, and the production of vascular permeability factors, TGF-, and fibronectin are triggered in an attempt to compensate for these changes [30]