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When evaluating diagnostic properties of DPS p-tau217, we assessed cutoffs derived with 90% sensitivity, 90% specificity or maximum Youdens Index for CSF or venous plasma biomarker positivity and computed their respective NPV and PPV based on the prevalence of biomarker positivity in the subset of participants with available data for each analysis
Researchers never published the full results, although a short write-up in 2005 reported that the second trial found a positive effect but that it didnt reach statistical significance
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